renal dosing of Fluconazole

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Fluconazole: Dose adjustment for renal impairment

Cockcroft-Gault CrCl estimates (using the creatinine clearance calculator) should be used for drug dosing rather than the automated MDRD eGFR produced by the clinical chemistry laboratory available on NOTIS.

Crcl (ml/min)	Dose
20 – 50	Normal
10 – 20	Normal
<10	50% of normal dose at normal frequency (minimum 50mg od). Oral dose minimum 50mg

No dosage adjustments are required if a single dose is only being given.

Refer to renal pharmacist for advice on dosing in haemodialysis and peritoneal dialysis.

Refer to critical care pharmacist for advice on dosing in CVVH.

Page last edited: 28/04/2009

Caution; the antibiotic doses recommended on this website are intended for adult patients with normal renal and liver function unless otherwise stated. Dosing advice for patients with renal impairment is available here.